Received July 17, 2022
Accepted December 01, 2022

Objective:The aim of this study was to observe whether or not the increase in the incidence of malformations in fetuses resulting from assisted reproductive technology. Methods:To this end, a survey was conducted in the bibliographic databases MEDLInE® with the following keywords: fetus malformations and assisted reproduction. We found a total of 65 articles. The study excluded 46 studies because they do not suit the subject or are not complete. 19 studies met the predetermined criteria and the limit on the selection period of publication from 1995 to 2011. Results:The results showed the sum of 620 malformations. The cardiac malformations were present in 40.2% of the surveyed cases. Changes in the abdominal wall and / or digestive tract in 22.3% of cases. The defects of bone formation by 13.2%, followed by the central nervous system disorders 7.7% and 7.0% with the genitourinary tract. Other isolated malformations or cumulative reached 9.7% of cases. We did not observe a significant increase in malformations among all live births, when compared with the incidence of malformations in the fetus not resulting from assisted reproduction techniques. Conclusion:Apparently it is concluded that there may be an increased risk of malformations in children born by IVF, when it was not provided a genetic investigation of the couple. Anyway, more studies are needed in order to clarify these aspects of human reproduction, particularly as regards to more appropriate rules to genetic testing.