Roberto Coco, A Mondadori, ME Ducatelli, J Mincman, A Gallo, F Coco, S Neuspiller, FL Gismondi, N Neuspiller
JBRA Assist. Reprod. 2012; 16 (5):268-270
Received November 08, 2012
Accepted December 18, 2012
Abstract
Objective: Advances in reprogenetics have allowed theequivalent blastocyst biopsy to chorionic villi. prenatal diagnosis. The major experience is with biopsy on day+3. While the results are satisfactory, the inconvenient is the study in only one or two cells, and no always the result is obtained. Biopsy in D +5 allows to remove more cells and the result almost is obtained.
Methods: We report our experience of 62 cycles performed in 43 patients with transfer after the stimulated cycle. The reasons were: monogenic disorder (15), reciprocal translocations (6), HLA typed (5), RHD (1), recurrent aneuploidy (5) and PGSS (2). Of the 62 cycles started, 61 were aspirated. Of the aspirates, 17 (28%) failed to reach blastocyst stage. Forty-five cycles (72%) reached blastocyst stage, 29 of them of good quality (group I) and 16 fair or poor quality (group II).
Results: Twelve pregnancies were achieved in 26 transfers transfers (46%), 11 in group I (52%) and 1 in group II (20%).
Conclusion: The results obtained allowed us to change program in D +3 with fresh transfer by biopsy on D+5 and transfer in another cycle, unstimulated, with better results than previous program on day 3.
