Received February 07, 2012
Accepted February 27, 2012

Objective: To compare the results of IVF cycles using different doses (10000 IU e 5000 IU) of urinary human chorionic gonadotropin for triggering final oocyte maturation. Methods: This is a prospective and observational study of 108 patients submitted to IVF/ICSI cycles, who had more than 15 follicles with a diameter > 17 mm on the day of hCG administration. The two groups were defined according to the doses of hCG they were administered ~36 hours before oocyte retrieval: Group 1 (10 000 IU) and Group 2 (5 000 IU), in a long protocol for controlled ovarian hyperstimulation. Results: Group 1 had 74 patients (mean age 33.46±3.9) and group 2 had 34 patients (mean age 32.43±5.4). All patients were submitted to egg collection with more than 15 follicles. Estradiol levels on the day of the hCG administration was 3567±620 in Group 1 and 4060±730 in group 2, p=0.38. The median number of mature oocytes was 15.21±3.7 (Group 1) and 21.4±5.22 (Group 2), p<0.001. There was no statistically significant difference between the groups in clinical PR, ongoing PR, miscarriage and in the incidence of severe Ovarian Hyperstimualation Syndrome. Conclusion: We observed that the use of a lower dose of urinary hCG (5000 IU) instead of the traditional dose (10000 IU) used for triggering final oocyte maturation, does not appear to adversely affect the IVF outcomes, and the incidence of severe OHSS was not different.