Received July 10, 2012
Accepted July 17, 2012

Objective: To verify the relationship between oocyte dysmorphisms and chromosomal abnormalities of in vitro-derived embryos. Methods: This retrospective study enrolled 189 intracytoplasmic sperm injection cycles associated with preimplantation genetic aneuploidy screening. The relationship between oocyte dysmorphisms and embryonic chromosomal abnormalities was evaluated. The influence of oocyte dysmorphisms on embryonic chromosomal aneuploidy was assessed using logistic regression and results are expressed as odds ratio (OR), confidence intervals (CI) and p-values. Results: Increased cytoplasmic granularity (OR: 1.68, CI: 1.10-2.56), enlarged (OR: 1.52, CI: 1.10-2.11) and granular perivitelline space (OR: 1.52, CI: 1.11-2.10) were determinants of increased likelihood of embryonic chromosomal alteration. Considering only female patients aged ≤ 35 years, enlarged perivitelline space (OR: 2.20, CI: 1.11–4.37) was determinant of the likelihood of embryonic chromosomal alteration. Conclusions: Oocyte cytoplasmic granulation, enlarged and granular perivitelline space are associated with increased probability of aneuploidy in the developing embryo.