Received July 17, 2022
Accepted December 01, 2022

Objectives: Human oocyte in vitro maturation is a state of the art technology for infertility treatment, particularly for patients with polycystic ovary syndrome or polycystic-like ovaries. Thus, the knowledge of embryonic developmental parameters post-IVM is paramount for the improvement of the technology and its outcomes. Our aim was to analyze the frequency of aneuploid zygotes and early cleavage embryos generated from in vitro matured oocytes. methods: Retrospective data analysis of 52 IVM cycles. Results: We observed that the frequency of aneuploid zygotes (1Pn or 3 Pn) of 20% is higher than that reported for stimulated cycles. On the other hand, detection of early cleavage embryos leads to higher chemical pregnancy and implantation rates in patients that received at least one early-cleavage embryo in the transfer cohort. Conclusions: Our data show that there is an increased rate of abnormal fertilization in IVM cycles, possibly due to an inadequate or incomplete cytoplasmic maturation ex-vivo. However, as in stimulated cycles, we observed the occurrence of early cleavage embryos and their transfer significantly increases implantation rates emphasizing the importance of detection and selection of these embryos for transfer.